Episode Description:
Herbal supplements can impact kidney function through several pathways. Some herbs contain compounds that are directly toxic to renal cells. For instance, aristolochic acid, found in herbal remedies for weight loss and rheumatism, can cause kidney disease due to its cytotoxic effects, leading to renal fibrosis and carcinoma.
High concentrations of oxalates in supplements derived from plants like star fruit or rhubarb can form crystals in the kidneys, leading to stone formation, urinary flow obstruction, and acute renal failure. Herbs such as licorice contain glycyrrhizin, which can alter renal hemodynamics by inhibiting cortisol degradation and mimicking aldosterone effects, leading to sodium retention, potassium depletion, and hypertension, adding strain to renal function. Immune-boosting supplements like Echinacea can trigger immune responses causing renal pathology, such as interstitial nephritis, which involves inflammation between renal tubules and can lead to chronic kidney damage if untreated.
Some studies indicate that individuals consuming high doses of green tea extracts experienced increased rates of acute kidney injury due to high levels of catechins, which can cause oxidative stress and tubular necrosis under certain conditions. Additionally, epidemiological data from East Asia, where traditional herbal medicines are common, show a significant link between the chronic use of herbs containing aristolochic acid and the development of end-stage renal disease.
Renes Care Radio is a podcast designed for nephrology professionals, offering in-depth scientific explorations of key topics. It equips kidney care providers with the essential knowledge needed for advanced patient care.
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This podcast is for informational purposes only and is not intended to replace professional medical advice, diagnosis, or treatment.